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Anti- Gα13 Mouse Monoclonal Antibody

價格¥1600.00
品牌NewEast Biosciences   
產地中國 武漢
貨號26004
規(guī)格100μl
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  • Gα13 [26004]
    [100 µL]

     

    Catalog Number:  26004
    Gene Symbol:  Gna13
    Description:   Anti Gα13 Mouse Monoclonal Antibody
    Background:   Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored.
    Immunogen:   Recombinant full length Gα13 protein
    Applications:   ELISA, WB, IHC
    Recommended Dilutions:   ELISA 1:1000-1:5000, WB 1:1000-1:2000
    Concentration:   1 mg/ml
    Host:   mouse
    Format:   Liquid
    Clonality:   Monoclonal
    Isotype:   IgG
    Purity:   Purified from ascites
    Storage buffer:
    Preservative:  no
    Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
    Species Reactivity:  13 monoclonal antibody recognizes Gα13 of vertebrates.
    Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
     
    Western blot:  
    Western blot analysis of Gα13 proteins. Gα13, Gα12 or Gαqplasmid DNAs were transiently transfected into CHO cells (endogenous Gα13 protein was down-regualted by Gα13siRNA). Whole-cell lysates were used for western blots.

     

    Related Products
    Catalog# Name Size Price
    80401 13 Activation Assay Kit  20 assays  ¥6800  
    26902 Active Gα13 GTP Monoclonal Antibody  30 μL  ¥4800
    26004 Anti Gα13 Mouse Monoclonal Antibody  100 μL  ¥2800
    21005 Anti Gα13 Rabbit Polyclonal Antibody  100 μL  ¥2600

     

     

    Publications:
    1.  Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization
        J Biol Chem. 2011 Sep 2;286(35):31055-61
    2.  Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2
        Br J Pharmacol. 2011 Feb;162(3):733-48
    3.  Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation
        Carcinogenesis (2010)
    4.  Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency
        J Biol Chem. 2009 Oct 2;284(40):27409-15

     

     

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