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neweastbio@126.com
| 027-87561033
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| 價格 | ￥1600.00 |
| 品牌 | NewEast Biosciences  |
| 產(chǎn)地 | 中國 武漢 |
| 貨號 | 21005 |
| 規(guī)格 | 100μl |
| 說明書 | 說明書下載 |
Gα13 [21005]
[100 µL]
| Catalog Number: 21005 |
| Gene Symbol: Ga13 |
| Description: Anti Gα13 Rabbit Polyclonal Antibody |
| Background: Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored. |
| Immunogen: Recombinant full length Gα13 protein |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA 1:100-1:5000 WB 1:100-1:2000 |
| Concentration: 1 mg/ml |
| Host: Rabbit |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: |
| Purity: Purified from serum |
| Storage buffer: |
| Preservative: no |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Gα13 polyclonal antibody recognizes Gα13 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles |
| Western blot: |
 |
Western blot analysis of Gα13 proteins. MEF whole-cell lysates were used for western blot with anti Gα13polyclonal antibody (Cat. # 21005). |
| Immunofluorescence: |
|
Immunofluorescence of mouse embryonic fibroblast (MEF) cells. Wild-type MEF cells (top panel) and Gα13 double knock-out cells (Gα13 -/-, bottom panel) were fixed and stained with anti-Gα13 polyclonal antibody (Cat. # 21005). Arrows indicate the dorsal ruffle strcture of one cell. |
| Related Products | |||
| Catalog# | Name | Size | Price |
| 80401 | Gα 13 Activation Assay Kit | 20 assays | ￥6800 |
| 26902 | Active Gα 13-GTP Monoclonal Antibody | 30 μL | ￥4800 |
| 26004 | Anti-Gα 13 Mouse Monoclonal Antibody | 100 μL | ￥2800 |
| 21005 | Anti-Gα 13 Rabbit Polyclonal Antibody | 100 μL | ￥2600 |
| Publications: |
| 1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem. 2011 Sep 2;286(35):31055-61 |
| 2. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2 Br J Pharmacol. 2011 Feb;162(3):733-48 |
| 3. Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation Carcinogenesis (2010) |
| 4. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem. 2009 Oct 2;284(40):27409-15 |
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