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Anti -IDH2 (R140Q) Mouse Monoclonal Antibody

價(jià)格¥4800.00
品牌NewEast Biosciences   
產(chǎn)地中國(guó) 武漢
貨號(hào)26165
規(guī)格100ul
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  • IDH2 (R140Q) [26165]
    [100ul

     

    Catalog Number:  26165
    Gene Symbol:  IDH2; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH
    Description:   Anti IDH2(R140Q) Mouse Monoclonal Antibody
    Background:   Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-132 in IDH to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
    Immunogen:   A synthetic peptide from the internal region of IDH2 which includes the mutation of R140Q, human origin.
    Applications:   ELISA, WB, IF, IHC
    Recommended Dilutions:   
    ELISA: 1:1000-1:5000 
    WB: 1:500-1:1000 
    IF: 1:50-1:100 
    IHC: 1:50-1:100
    Concentration:   1 mg/ml
    Host:   Mouse
    Format:   Liquid
    Clonality:   Monoclonal
    Isotype:   
    Purity:   Purified from ascites
    Storage buffer:
    Preservative:  no
    Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
    Species Reactivity:  Recognizes R140Q mutant, but not wild-type IDH2 of vertebrates.
    Storage Conditions:   Store at -20°C. Avoid freeze / thaw cycles
     
    Western blot:  
    Western blot analysis of recombinant IDH2(R140Q) and wildtype proteins. Purified His-tagged IDH2(R140Q) protein (lane 2) and corresponding wildtype protein (lane 1) were blotted with anti IDH2(R140Q) monoclonal antibody (Cat. #26165).
    Immunofluorescence:  
    Immunofluorescence of cells expressing IDH2 proteins with anti IDH2(R140Q) antibody. HEK293T cells were transfected with pCDNA3-GFP-IDH2 (WT) plasmid (left column) or pCDNA3-GFP-IDH2(R140Q) plasmid (right column), then fixed and stained with anti-IDH2(R140Q) monoclonal antibody (Cat. #26165).

     

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    Publications:
     
    1.  Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
        Nature 513, 110–114 (04 September 2014)
    2.  Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism
        Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015

     


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