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價(jià)格 | ¥4800.00 |
品牌 | NewEast Biosciences |
產(chǎn)地 | 中國 武漢 |
貨號(hào) | 26121 |
規(guī)格 | 100ul |
說明書 | 說明書下載 |
EGFR(V769L) [26121]
[100 µL]
Catalog Number: 26121 |
Gene Symbol: EGFR/HER1/ERBB1 |
Description: Anti EGFR(V769L) Mouse Monoclonal Antibody |
Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
Immunogen: A synthetic peptide from the internal region of EGFR which includes the mutation of V769L, human origin. |
Tseted Applications: ELISA, WB, If, IHC |
Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:2000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: |
Purity: Purified from ascites |
Storage buffer: |
Preservative: no |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes EGFR(V769L), but not wild type EGFR from vertebrates. |
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles. |
Western blot: |
Western blot analysis of recombinant EGFR(V769L) and wildtype proteins. Purified His-tagged EGFR(V769L) protein (amino acids 702-987, lane 2, Cat. #10239) and corresponding wild type protein (lane 1, Cat. #10210) were blotted with anti EGFR(V769L) mouse monoclonal antibody (Cat. #26121). Proteins loading (bottom) were blotted with anti-His-tag monoclonal antibody (Cat. #28004). |
Immunofluorescence: |
Immunofluorescence of cells expressing EGFR proteins with anti EGFR(V769L) antibody. HEK293T cells were transfected with pCDNA3-GFP EGFR(WT) plasmid (left column) or pCDNA3-GFP EGFR(V769L) plasmid (right column), then fixed and stained with anti EGFR(V769L) monoclonal antibody (Cat. # 26121). |
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