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價(jià)格 | ¥4800.00 |
品牌 | NewEast Biosciences |
產(chǎn)地 | 中國(guó) 武漢 |
貨號(hào) | 26119 |
規(guī)格 | 100ul |
說(shuō)明書(shū) | 說(shuō)明書(shū)下載 |
EGFR(G863D) [26119]
[100 µL]
Catalog Number: 26119 |
Gene Symbol: EGFR/HER1/ERBB1 |
Description: Anti EGFR(G863D) Mouse Monoclonal Antibody |
Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
Immunogen: A synthetic peptide from the internal region of EGFR which includes the mutation of G863D, human origin. |
Tested Applications: ELISA, WB, IF, IHC |
Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:1000-1:5000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: |
Purity: Purified from ascites |
Storage buffer: |
Preservative: no |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes EGFR(G863D), but not wild type EGFR from vertebrates. |
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles. |
Western blot: |
Western blot analysis of recombinant EGFR(G863D) and wildtype proteins. Purified His-tagged EGFR(G863D) protein (amino acid 702-987) (Cat. #10222) and corresponding wild-type protein (Cat. #10210) were blotted with anti EGFR(G863D) mouse monoclonal antibody (Cat. #26119). Proteins loading were blotted with anti-His-tag monoclonal antibody (Cat. #28004). | |
Immunofluorescence: |
Immunofluorescence of cells expressing EGFR proteins with anti EGFR(G863D) antibody. HEK293T cells were transfected with pCDNA3-GFP EGFR(WT) plasmid (left column) or pCDNA3-GFP EGFR(G863D) plasmid (right column), then fixed and stained with anti-EGFR(G863D) monoclonal antibody (Cat. #26119). |
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